NMDA receptor 1 (NMDAR1)

Normal neuroanatomy
No effect on pathfinding, initial targeting, or crude topographic projection of trigeminal patches in the brain stem

Abnormal neuron responses

Elimination of NMDA-inducible increase in intracellular calcium and membrane currents

Reduction in levels of NR2B but not NR2A
Absence of whisker-related neuronal patterns in the trigeminal brainstem nuclei
Severe ataxia
Death shortly after birth

((nmdar1))

	Line Name	DNA Construct
1.	NMDAR1 (+/-)	To determine the copy number of NMDAR1 (N-methyl-D-aspartate receptor 1) gene in the mouse genome, genomic DNA isolated from mouse D3 ES cells was digested by BamHI....
2.	NMDAR1 (-/-)	To determine the copy number of NMDAR1 (N-methyl-D-aspartate receptor 1) gene in the mouse genome, genomic DNA isolated from mouse D3 ES cells was digested by BamHI....