Myogenin

Major defects in skeletal muscle

Disappearance of most cells in latero-ventral body wall

Severe disruption of myogenic cells in the limbs

Mono-nucleate cells with properties of myoblasts

Disorganized fibers in axial, intercostal, and back muscles

Absence of Z-lines in most myofibrils

Severe reduction of all skeletal muscle

Death immediately after birth

((myogenin))

	Line Name	DNA Construct
1.	myg(ml)/+	The mouse myogenin gene, located on chromosome 1, contains three exons and two introns spanning 2.5 kb of DNA. To target the myogenin sequences in embryonic stem cells,....
2.	myogenin-LacZ UGHZ	It was observed that the sequences between -1092 and -134 exert a marked effect on the efficiency of expression (refer to myogenin-LacZ GZ133 (TG-000-00-838) and myogeni....
3.	MyoG(mt-1) (+/-)	The murine genomic myogenin DNA fragment was isolated from a BALB/c genomic library. A 3.5-kb genomic DNA fragment extending from an EcoRI site in the 5' ups....
4.	myg(ml)/myg(ml)	The mouse myogenin gene, located on chromosome 1, contains three exons and two introns spanning 2.5 kb of DNA. To target the myogenin sequences in embryonic stem cells,....
5.	LacZ/beta-globin BZ	To construct RSEGZ, the myogenin-human beta-globin -lacZ fusion gene, the myogenin 5' flanking sequences between -192 and -55 were generated by PCR with pGSM as template....
6.	myogenin-LacZ GMEZ1	Cosmid M8B was isolated by screening from a T-cell clone of C57BL6 origin in the vector cos202 (Dimitris Kioussis, NIMR, London) with a mouse myogenin cDNA probe. A 5.6....
7.	myogenin-LacZ GMEZ1	Cosmid M8B was isolated by screening from a T-cell clone of C57BL6 origin in the vector cos202 (Dimitris Kioussis, NIMR, London) with a mouse myogenin cDNA probe. A 5.6....
8.	myogenin-beta-globi	To construct RSEGZ, the myogenin-human beta-globin -lacZ fusion gene, the myogenin 5' flanking sequences between -192 and -55 were generated by PCR with pGSM as template....
9.	myogenin-LacZ GZ188	Cosmid M8B was isolated by screening from a T-cell clone of C57BL6 origin in the vector cos202 (Dimitris Kioussis, NIMR, London) with a mouse myogenin cDNA probe. A 5.6....
10.	myogenin-LacZ GZ165	Cosmid M8B was isolated by screening from a T-cell clone of C57BL6 origin in the vector cos202 (Dimitris Kioussis, NIMR, London) with a mouse myogenin cDNA probe. A 5.6....
11.	myogenin-LacZ GZ425	Cosmid M8B was isolated by screening from a T-cell clone of C57BL6 origin in the vector cos202 (Dimitris Kioussis, NIMR, London) with a mouse myogenin cDNA probe. A 5.6....
12.	myogenin-LacZ GZ338	Cosmid M8B was isolated by screening from a T-cell clone of C57BL6 origin in the vector cos202 (Dimitris Kioussis, NIMR, London) with a mouse myogenin cDNA probe. A 5.6....
13.	MyoG(mt-1) (-/-)	The murine genomic myogenin DNA fragment was isolated from a BALB/c genomic library. A 3.5-kb genomic DNA fragment extending from an EcoRI site in the 5' ups....
14.	myogenin-LacZ GZ133	Cosmid M8B was isolated by screening from a T-cell clone of C57BL6 origin in the vector cos202 (Dimitris Kioussis, NIMR, London) with a mouse myogenin cDNA probe. A 5.6....
15.	myogenin-LacZ GMEZ1	Cosmid M8B was isolated by screening from a T-cell clone of C57BL6 origin in the vector cos202 (Dimitris Kioussis, NIMR, London) with a mouse myogenin cDNA probe. A 5.6....
16.	myogenin-LacZ GZ109	Cosmid M8B was isolated by screening from a T-cell clone of C57BL6 origin in the vector cos202 (Dimitris Kioussis, NIMR, London) with a mouse myogenin cDNA probe. A 5.6....
17.	myogenin-LacZ GMRZ1	Cosmid M8B was isolated by screening from a T-cell clone of C57BL6 origin in the vector cos202 (Dimitris Kioussis, NIMR, London) with a mouse myogenin cDNA probe. A 5.6....
18.	myogenin-LacZ EGMEZ	Cosmid M8B was isolated by screening from a T-cell clone of C57BL6 origin in the vector cos202 (Dimitris Kioussis, NIMR, London) with a mouse myogenin cDNA probe. A 5.6....