Myf-5 and MyoD

 Born alive but immobile
 Complete absence of skeletal muscle
 Absence of desmin-expressing myoblast-like cells

 Death soon after birth

Rudnicki et al., 1993


METHODOLOGY ( FROM T-BASE)

((myod/myf5))

Line Name DNA Construct
1. OVE78 The mouse alpha A-crystallin promoter was linked to the myogenesis factor myoD.
2. OVE78 The mouse alpha A-crystallin promoter was linked to the myogenesis factor myoD.
3. MyoD/MyoD(m1) (+/-) To facilitate construction of an efficient replacement-type vector, the MyoD genomic locus was cloned from a lambda library constructed from DNA isolated from 129/Sv mic....
4. MyoD(m1)/MyoD(m1) ( To facilitate construction of an efficient replacement-type vector, the MyoD genomic locus was cloned from a lambda library constructed from DNA isolated from 129/Sv mic....
5. bmyf (Myf5) #25-37 To construct the transgene, a 1,945-bp EcoRI restriction fragment bearing a full length bmyf (the bovine homolog of myf) cDNA was inserted into a unique ....
6. bmyf (Myf5) #25-2/6 To construct the transgene, a 1,945-bp EcoRI restriction fragment bearing a full length bmyf (the bovine homolog of myf) cDNA was inserted into a unique ....
7. bmyf (Myf5) #26 To construct the transgene, a 1,945-bp EcoRI restriction fragment bearing a full length bmyf (the bovine homolog of myf) cDNA was inserted into a unique ....
8. Myf-5/lacZ A classical positive/negative selction vector (G00-372-934) was used containing 5.5 kbp and 1.1 kbp of the myf-5 (myogenic factor-5) locus flanking the lacZ and neomycin....
9. Myf-5(m1)/Myf-5(m1) Probes from the untranslated 3' ends of the mouse Myf-5 and Myf-6 cDNAs were used to isolate a set of overlapping lambda clones from a genomic library constructed from D....


Database links: MYF5

OMIM MEDLINE Citations Protein Links Nucleotide Links Gene Map GDB MEDLINE Neighbors

Database links: MYOD

OMIM MEDLINE Citations Protein Links Nucleotide Links Gene Map GDB MEDLINE Neighbors