Lyn

Abnormal B lymphocyte lineage and mast cell function
Immunoglobulin M hyperglobulinemic
Affected immune responses to T-independent and T-dependent antigens
Failure to mediate an allergic response to IgE cross-linking
Circulating autoreactive antibodies
Severe glomerulonephritis due to deposition of IgG immune complexes in the kidney

Hibbs, 1995

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease.
Cell 83, 301-311 (1995) [96028104]
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( (lyn))

	Line Name	DNA Construct
1.	CSK/pNZ-DT (+/-)	In pNZ-DT, the DNA fragment from a Kpnl site in the 5'-non-coding exon to an Ncol site in the kinase domain was replaced with lacZ and neo(r) genes. Since the translatio....
2.	CSK/pNZ-DT (-/-)	In pNZ-DT, the DNA fragment from a Kpnl site in the 5'-non-coding exon to an Ncol site in the kinase domain was replaced with lacZ and neo(r) genes. Since the translatio....
3.	Src (-/-)	A replacement vector, src 22, was made using the Pol2sneobpA cassette. This cassette was chosen because the use of a weaker promoter may reduce the number of G418(r) co....
4.	CSK/pCZ-DT (-/-)	To introduce mutations into the csk gene by homologous recombination in ES cells, 2 types of targeting vector were constructed. The pCZ-DT vector has lacZ and neo[r] (n....