Lymphotoxin

Normal thymus development
Normal ratio of CD4+CD8- and CD4-CD8+ T cells
Normal T cell lytic function
Increased number of IgM positive lymphocytes in spleen and peripheral blood
No morphologically detectable lymph nodes or Peyer's patches
Failure of normal segregation of B and T cells in spleen

De Togni et al., 1994

Defects in secondary lymphoid organ development in mice
Lack of lymph nodes and Peyer's patches
Disruption of spleen structure
Accumulation of abnormal clusters of lymphocytes in periportal and perivascular regions of the liver and the lung
Normal lymphocytes with expected ratios of B and T cell surface markers, also L-selectin, the lymphocyte homing marker
Ability of bone marrow cells to successfully reconstitute the lymphoid organs of severe immunodeficient mice
Impaired humoral immune responsiveness to Ag

Banks, 1995

Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness.
J Immunol 155, 1685-1693 (1995) [95363136]
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Abnormal development of secondary lymphoid tissues
Significant lymphocytosis in the circulation and peritoneal cavity
Lymphocytic infiltrations in lungs and liver

Reference:

Alimzhanov MB, Kuprash DV, Kosco-Vilbois MH, Luz A., Turtskaya RL, Tarakhovsky A., Rajewsky K., Nedospasov SA, Pfeffer K.: Abnormal development of secondary lymphoid tissues in Lymphotoxin beta. Proc Natl Acad Sci USA 1997 Aug 19;94 (17):9302-9307.

((lymphotoxin))

	Line Name	DNA Construct
1.	LT (+/-)	The trageting vector was constructed by replacing a small portion of the second exon, the entire third exon, and a small portion of the fourth exon of the gene encoding....
2.	LT (-/-)	The trageting vector was constructed by replacing a small portion of the second exon, the entire third exon, and a small portion of the fourth exon of the gene encoding....