FRONTIERS IN BIOSCIENCE; GENE KNOCKOUT DATABASE
	IL-7 Ten to twenty fold reduction in the total number of T and B cells Sharp reduction in frequency and absolute number of adult thymic gamma/delta T cells Retention of normal frequency of alpha beta T cells Lack of splenic and intestinal intraepithelial gamma/delta T cells Impaired fetal gamma/delta T cell maturation Inhibition in differentiation of immature Vgamma3lowCD24+ fetal Tcells to mature Vgammma3highCD24- cells NK cell maturation mildly affected Partial inhibition in the differentiation of CD44+25+ pro-T cells into CD44-25+ pre-T cells Decreased expression of CD117 (c-kit) on both CD4low and pro-T cells Moore, U. von Freeden-Jeffry, R. Murray & A. Zlotnik: Inhibition of gamma/delta T Cell Development and Early Thymocyte Maturation in IL-7 -/- Mice1. The Journal of Immunology 157, 2366-73 (1996) Database Links