IL-4

Blockage of Th2 cytokine response

Failure to respond to oral administration of soluble protein antigens

Lack of or poor B cell responses to anti-keyhole limpit hemocyanin or anti-ovalbumin in the gut lamina propria, spleen, and serum

Failure to stimulate antigen-specific T cell responses after mucosal immunization

Complete inability to form germinal centers in Peyer's patches

Ability to control and clear a primary infection with Plasmodium chabaudi

Significantly higher rate of recrudescent parasitemia

((il-4))

	Line Name	DNA Construct
1.	129/Sv IL-4	Murine ES cells were transfected with an interleukin-4 (IL-4) expression vector (Citation G00-311-102) in which the IL-4 cDNA is regulated by an immunoglobulin heavy cha....
2.	IL4T (+/-)	The targeting vector used for the disruption of the IL-4 gene contains a 4.5-kb Bam HI-EcoRI fragment, which includes the first two exons of the IL-4 gene. Th....
3.	IL4T (-/-)	The targeting vector used for the disruption of the IL-4 gene contains a 4.5-kb Bam HI-EcoRI fragment, which includes the first two exons of the IL-4 gene. Th....
4.	IL-4 (+/-)	The targeting vector p5420 consisted of the neomycin neo(r) cassette which contains the 1.2-kb XhoI-SalI fragment of the plasmid pMC1Pol(A) (Strata....
5.	IL-4 (+/-)	The targeting vector p5420 consisted of the neomycin neo(r) cassette which contains the 1.2-kb XhoI-SalI fragment of the plasmid pMC1Pol(A) (Strata....