IL-2
Normal T cell maturation
Normal development of all major lymphoid subsets in homozygous mice
Normal Fas expression
Eventual develpoment of fatal immunopathology
In vivo CD4+ and CD8+ T cell expansion against superantigens
Diminished subsequent deletions of CD4+ cells
Absence of anergy in residual superantigen-reactive cells fail
Absence of Fas-induced apoptosis cultured on anti-Fas antibody-coated plates
Absence of IL-2 may fail to generate a necessary signal activating apoptosis
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Kneitz, 1995
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Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice.
Eur J Immunol 25, 2572-2577 (1995) [96011869]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 Related MEDLINE citations )
Schorle et al., 1991
| Line Name | DNA Construct | |
|---|---|---|
| 1. | IL-2 (+/-) | A neomycin resistance gene cassette from pMC1neopA (neo(r)), was inserted in reverse orientation into the third exon of the mouse IL-2 gene cloned into pUC19. This 1.1.... |
| 2. | IL-2 (+/-) | A neomycin resistance gene cassette from pMC1neopA (neo(r)), was inserted in reverse orientation into the third exon of the mouse IL-2 gene cloned into pUC19. This 1.1.... |
| 3. | IL-2 (-/-) | A neomycin resistance gene cassette from pMC1neopA (neo(r)), was inserted in reverse orientation into the third exon of the mouse IL-2 gene cloned into pUC19. This 1.1.... |
| 4. | IL-2 (-/-) | A neomycin resistance gene cassette from pMC1neopA (neo(r)), was inserted in reverse orientation into the third exon of the mouse IL-2 gene cloned into pUC19. This 1.1.... |
