IL1 Type I Receptor

Normal vigor
Normal serum Ig levels
Normal primary and secondary antibody responses
Normal response of acute phase protein mRNA induction to LPS injection
No overt phenotype
No detectable change in serum IL6 in response to IL1 injection

Reference:

Glaccum MB, Stocking KL, Charrier, K, Smith JL, Willis CR, Maliszewski C, Livingston DJ, et al.: Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J Immunol 1997 Oct 1;169 (7):3364-3371.

Viable
Normal fertility
Normal IL-1 induced IL-6 expression
Normal IL-1 induced E-selection expression
Normal IL-1 induced fever expression
Reduced acute phase response to tuprntine
Delayed reduced-type hypersensitivity
Increased susceptability to infection by Listeria monocytogenes

Reference:

Labow M., Shuster D., Zetterstrom M., Nunes P., Terry R., Cullinan EB, Bartfai T., Solorzano C., Moldawer LL, Chizzonite R., McIntyre KW.: Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. J Immuno 1997 Sep 1;159 (5):2452-2461.