IL-18 (IGIF)

Viable
Fertile
No evident histopathological abnormalities
Susceptibility to Leishmania major infection
Susceptibility to Stophylococcus aureus infection (developed more severe
Septic arthritis and markedly less septicaemia)
Significantly reduced Th1 type of immune response and enhanced Th2 type of immune response.

Wei et al, 1999

Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice. J Immunol. 163(5):2821-28281(999) PMID: 10453027; UI: 99384107