Impairment of liver regeneration characterized by liver necrosis and failure
Blunted DNA synthetic response in hepatocytes, not in nonparenchymal liver cells
Discrete G1 phase (prereplicative stage in the cell cycle) abnormalities
Absent STAT3 (signal transducer and activator of transcription protein 3) activation
Depression of AP-1, Myc, and cyclin D1 expression

Cressman, L. E. Greenbaum, R. A. DeAngelis, G. Ciliberto, E. E. Furth, V. Poli & R. Taub:
Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6--Deficient Mice.
Science 274, 1379 (1996)

Increased susceptability to C. albicans infection
Fail to mount Th1-associated protective immunity
Severe impairment of macrophage and neutrophil response to infection

((il-6))

	Line Name	DNA Construct
1.	IL-6 (+/-)	The IL-6 (interleukin-6) target vector with a short arm and long arm homology of 1.4 kb and 8.5 kb, respectively, contains the neo cassette cloned in exon 2 (first codin....
2.	IL-6 (-/-)	An IL-6 genomic clone derived from a Balb/c genomic library was used a source of IL-6 genomic sequences. The 5' homology, a 1-kb SpeI-AatII fragme....
3.	IL-6 (+/-)	An IL-6 genomic clone derived from a Balb/c genomic library (G00-097-505) was used as a source of IL-6 genomic sequences. The 5' homology, a 1 kb SpeI-A....
4.	(MR16-1)-treated L(	C57BL/6J L(d)-IL-6 transgenic mice were produced by microinjection of the 3.3-Kbp SphI-XhoI fragment (L(d)-IL-6) containing human IL-6 cDNA fused w....
5.	IL-6 (-/-)	The IL-6 (interleukin-6) target vector with a short arm and long arm homology of 1.4 kb and 8.5 kb, respectively, contains the neo cassette cloned in exon 2 (first codin....
6.	IL-6 (-/-)	An IL-6 genomic clone derived from a Balb/c genomic library (G00-097-505) was used as a source of IL-6 genomic sequences. The 5' homology, a 1 kb SpeI-A....
7.	L(d)-IL-6	C57BL/6J L(d)-IL-6 transgenic mice were produced by microinjection of the 3.3-Kbp SphI-XhoI fragment (L(d)-IL-6) containing human IL-6 cDNA fused w....
8.	PEPCK/hsIL-6R	A 1.1-kb cDNA fragment coding for the extracellular part of hIL-6R (human interleukin 6 receptor) was amplified by PCR and cloned into the SalI site of the pT....