Interleukin-2 receptor beta

Normal growth until 3 weeks after birth
Fuzzy hair
Slow movement
Poorly developed external genitals
Normal expression of IL-2 receptor alpha at 1-3 weeks of age
Decreased thymocytes by 6 weeks of age
Splenomegaly and lymphadenopathy containing large blasting TCR alpha beta T cells by 3 weeks of age
Spontaneous activation of T cells

Exhaustive differentiation of B cells to plasma cells

High serum concentration of IgG1 and IgE

Serum autoantibodies

Hemolytic anemia

Death at approximately 12 weeks

Currently, there are no entries for Interleukin-2 receptor beta, or variations of Il-2rb knockout methodologies in mouse.