Immunoglobulin mu chain

Arrest in B cell development

Kitamura et al., 1991
Kitamura and Rajewsky, 1992

((vdj-cmu))

	Line Name	DNA Construct
1.	VDJ-Cmu ES	The VDJ-Cmu expression vector (where Cmu represents the constant region) was constructed by ligating a 4.2 kb EcoRI fragment containing a functionally assembl....
2.	RAG-2(-/-)/VDJ-Cmu	RAG-2(-/-)-deficient mice were injected with VDJ-Cmu-transfected JH-/- ES cells. The VDJ-Cmu expression vector (where Cmu represents the constant region) was constructe....
3.	JH(-/-) ES	The internal 1.7-kb ApaI-Nae I fragment containing all four JH (H should be in subscript) gene segments in the 5.7-kb EcoRI-Ssp I genomic fragment....
4.	JH(+/-) ES	The internal 1.7-kb ApaI-Nae I fragment containing all four JH (H should be in subscript) gene segments in the 5.7-kb EcoRI-Ssp I genomic fragment....