Immunoglobulin heavy-chain joining region

Blockage of B cell development
Blockage of antibody production

Jakobovits et al., 1993

((igh))

	Line Name	DNA Construct
1.	J[H] (+/-)	Plasmid pUC18-J[H], containing a 6.1-kb EcoRI genomic fragment of the mouse Ig heavy-chain (Igh) locus, was digested with Xhol and Nael to delete the 2296-bp....
2.	J[H] (-/-)	Plasmid pUC18-J[H], containing a 6.1-kb EcoRI genomic fragment of the mouse Ig heavy-chain (Igh) locus, was digested with Xhol and Nael to delete the 2296-bp....