Insulin-like growth factor I receptor (Igf1r)

Inability of fibroblasts to be transformed by simian virus 40, large tumor antigen, or other oncogenes
Severe growth deficiency
Generalized organ hypoplasia
Developmental delays in ossification
Abnormalities in central nervous system
Abnormalities in epidermis
Death at birth due to respiratory failure

Liu et al., 1993
Li et al., 1994

Currently, there are no entries for Igf-1 receptor knockout methodologies in mouse.