Immunoglobulin D

Normal immune responses to thymus-independent and -dependent antigens

Development of normal germinal centers

Near-normal serum concentrations of the immunoglobulin isotypes

Normal pre-B-cell compartment

Reduced B-cell compartment

((igd))

	Line Name	DNA Construct
1.	IgD(a)/IgD(b) (+/-)	The targeting vector for IgD contained one exon of the constant region (Cdelta3) and exons for the secretory and membrane-spanning part of the protein (deltaS, deltaX, d....
2.	IgD/IgD (-/-)	The targeting vector for IgD contained one exon of the constant region (Cdelta3) and exons for the secretory and membrane-spanning part of the protein (deltaS, deltaX, d....