IFN-gamma receptor

Normal development
Deficiency in natural resistance
Aberrant response to innoculation with live attenuated pseudorabies virus (PRV)

Normal IFN-gamma and IL-2 production in PRV-immune animals exposed to viral antigen or Con A

No detectable IL-4 production in PRV-immune animals exposed to viral antigen or Con A

Lack of infectivity titers in various tissues

Transient viral antigen expression only in the spleen

Increased proliferative splenocyte responses and decreased IL-10 secretion

Significantly less antiviral (PRV) antibody produced in response to challenge infection

Increased mortality

Elevated levels of IgE and IgG1
Impaired ability to resolve a lung inflammatory response
Prolonged capacity of T cells to exhibit a Th2 cytokine profile
Higher levels of IL-4 and IL-5 production by lung derived T cells 1 to 2 months after ova challenge

Coyle, S. Tsuyuki, C. Bertrand, S. Huang, M. Aguet, S. S. Alkan & G. P. Anderson: Mice Lacking the IFN-gamma Receptor Have an Impaired Ability to Resolve a Lung Eosinophilic Inflammatory Response Associated with a Prolonged Capacity of T Cells to Exhibit a Th2 Cytokine Profile. The Journal of Immunology 156, 2680-2685 (1996)

((ifn-gamma receptor))

	Line Name	DNA Construct
1.	IFN-gamma R (+/0) (	Gene targeting of the murine IFN-gamma R gene and germline transmission of the disrupted allele was done as follows: Using the murine IFN-gamma Receptor cDNA as a probe....
2.	IFN-gamma R (0/0) (	Gene targeting of the murine IFN-gamma R gene and germline transmission of the disrupted allele was done as follows: Using the murine IFN-gamma Receptor cDNA as a probe....
3.	IFN-gammaR (+/-)	Gene targeting of the murine IFN-gamma R gene and germline transmission of the disrupted allele was done as follows: Using the murine IFN-gamma R cDNA as a probe, parti....
4.	IFN-gamma R (-/-)	Gene targeting of the murine IFN-gamma R gene and germline transmission of the disrupted allele was done as follows: Using the murine IFN-gamma R cDNA as a probe, parti....