FRONTIERS IN BIOSCIENCE;
GENE KNOCKOUT DATABASE





IFN-gamma receptor

Elevated levels of IgE and IgG1
Impaired ability to resolve a lung inflammatory response
Prolonged capacity of T cells to exhibit a Th2 cytokine profile
Higher levels of IL-4 and IL-5 production by lung derived T cells 1 to 2 months after ova challenge

Coyle, S. Tsuyuki, C. Bertrand, S. Huang, M. Aguet, S. S. Alkan & G. P. Anderson:
Mice Lacking the IFN-gamma Receptor Have an Impaired Ability to Resolve a Lung Eosinophilic Inflammatory Response Associated with a Prolonged Capacity of T Cells to Exhibit a Th2 Cytokine Profile.
The Journal of Immunology 156, 2680-2685 (1996)