IL-1-Beta Converting Enzyme
Normal development
Absence of IL-1-beta or IL-alpha export after stimulation with polysaccharide
Diminished export of TNF-alpha and IL-6
Thymocytes sensitivity to apoptosis induced by dexamethasone or ionizing radiation
Thymocytes resistance to apoptosis induced by Fas antibody
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Kuida, 1995
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Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.
Science 267, 2000-2003 (1995) [95215846]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 Related MEDLINE citations )
| Line Name | DNA Construct | |
|---|---|---|
| 1. | ICE (+/-) | A partial murine ICE (IL-1beta-converting enzyme) cDNA was isolated form a mouse macrophage cDNA library (Stratagene) by using a full-length human ICE coding sequence (p.... |
| 2. | ICE (-/-) | A partial murine ICE (IL-1beta-converting enzyme) cDNA was isolated form a mouse macrophage cDNA library (Stratagene) by using a full-length human ICE coding sequence (p.... |
| 3. | IL-1-beta (-/-) | A 4.6-kb |
