Early defect in polymorphonuclear leucocytes (PMN) accumulation at the site of infection, in vivo
PMN deficient in beta3 integrin-dependent ligand binding, in vitro
PMN deficient in activation of oxidative burst, in vitro
PMN deficient in Fc receptor-mediated phagocytosis, in vitro
Death due to Escherichia coli peritonitis at innocula which did not cause death in heterozygotes

Lindberg, D. C. Bullard, T. E. Caver, H. D. Gresham, A. L. Beaudet & E. J. Brown:
Decreased Resistance to Bacterial Infection and Granulocyte Defects in IAP-Deficient Mice.
Science 274, 795 (1996)