Hoxd-3

Radically remodeled craniocervical joint

Transformation of the anterior arch of atlas to an extension of the basioccipital bone of the skull

Lateral masses of the atlas resemble the exoccipitals

Fusion of lateral masses of the atlas with the exoccipitals

Abnormal formation of the second cervical vertebra

Deletion of superior facets and dens

Differential effects (i.e. deletion of parts of the vertebra or homeotic transformation to more anterior structures) on different parts of the same vertebra

Condie and Capecchi, 1993

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METHODOLOGY ( FROM T-BASE)

((hoxd-3))

	Line Name	DNA Construct
1.	Hoxd3 (Hox-4.1) (+/	A genomic clone that carries the Hoxd-3 gene was isolated by reduced stringency hybridization of a 51-mer oligonucleotide with a genomic lambda library prepared from DNA....
2.	Hoxd3 (Hox-4.1) (-/	A genomic clone that carries the Hoxd-3 gene was isolated by reduced stringency hybridization of a 51-mer oligonucleotide with a genomic lambda library prepared from DNA....

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Database links