Helix-loop-helix gene E2A

Development to full term
Normal development of T cells, granulocyte, macrophages, and erythroid cells
Retardation of postnatal growth
Deficient B cells

Blockage of B cell differentiation prior to Ig gene DH-JH rearrangement and B220 marker expression

Zhuang et al., 1994

((e2a))

	Line Name	DNA Construct
1.	E2A (+/-)	A 129/Ola genomic phage library was screened with a 200 bp PvuII fragment of the mouse E12 cDNA. One lambda clone was obtained that contained both the E12- a....
2.	E2A (-/-)	A 129/Ola genomic phage library was screened with a 200 bp PvuII fragment of the mouse E12 cDNA. One lambda clone was obtained that contained both the E12- a....