H2-M

Normal class II cell surface levels
Efficient positive selection of CD4+ cells
Poor whole protein and short peptide presentation
Reaction of peripheral T-cells to splenocytes form syngenic wild-type mice
Defective peptide loading of class II molecules
Reduced capacity for exogenous peptides presentation
Three- to four-fold reduction in mature CD4+ T lymphocytes
Alteration of lymphocyte reactivity