GluR-B

Synthesis of unedited-GluR-B subunits by heterozygous mice
Expression of AMPA receptors with increased calcium permeability in principal neurons and interneurons
Early-onset epilepsy
Postnatal lethality

Brusa, 1995

Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice.
Science 270, 1677-1680 (1995) [96099404]
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( (glur-b))

	Line Name	DNA Construct
1.	GluR-B (DELTA-ECS)	To investigate in an animal model the relevance of Q/R site editing for central nervous system physiology, Brusa et al. (1995) targeted intron 11 of the GluR-B gene in m....