ErbB4

 Homozygous mice

 Alterations in the innervation of the hindbrain in the CNS
 Aborted development of myocardial trabeculae in the heart ventricle
 Death during mid-embryogenesis

Gassmann, 1995
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor
Nature 378, 390-394 (1995) [96077110]
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METHODOLOGY ( FROM T-BASE)

( (erbb4))

( (erbb4))

Line Name DNA Construct
1. ErbB4 (+/-) The ErbB4 gene is >100 kb in length, and the lambda phage clone used for preparation of the targeting construct (pPNT-based vector) contains only coding sequence from th....
2. ErbB4 (-/-) The ErbB4 gene is >100 kb in length, and the lambda phage clone used for preparation of the targeting construct (pPNT-based vector) contains only coding sequence from th....
3. neuregulin (exon 7- Genomic neuregulin DNA isolated from a library of 129 mouse DNA (isogenic to ES cell line E14) was used to construct a tartgeting vector. In this, exon 7, 8, and 9, enc....
4. ErbB2 (-/-) A targeting vector in which a BamHI-XbaI 2.0-kb fragment containing the promoter and the first exon was replaced by a PGK-neomycin cassette. This....


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