Wurst, 1994

Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum.
Development 120, 2065-2075 (1994) [95009535]
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( (en-1))

	Line Name	DNA Construct
1.	En-1 (hd) (+/-)	For the targeting vector G, En-1 genomic sequences from the 129 mouse strain were used. The long arm consists of a 5.4 kb EcoRI-BglII genomic frag....
2.	En-1 (hd) (-/-)	For the targeting vector G, En-1 genomic sequences from the 129 mouse strain were used. The long arm consists of a 5.4 kb EcoRI-BglII genomic frag....
3.	En-2 (hd) (-/-)	The En-2 mutation created by homologous recombination resulted in the replacement of approximately 1-kb of the engrailed-2 En-2 gene, consisting of 300-bp of intron and....
4.	En-2 (ntd) (-/-)	An exon 1 En-2 (engrailed-2) targeting vector of the positive/negative type (Mansour et al., 1988; G00-372-934) was made from genomic DNA from C3H strain mice. The vect....
5.	En-1 in Wnt-1(+/-)	The neo cassette used was a modification of pMC1neopA (Thomas and Capecchi et al., 1987; G00-354-270). Initially, a neo-tk cassette was constructed by cloning a Bg....
6.	En-2 (hd) (-/-)	The En-2 mutation created by homologous recombination resulted in the replacement of approximately 1-kb of the engrailed-2 En-2 gene, consisting of 300-bp of intron and....
7.	En-1 in Wnt-1(-/-)	The neo cassette used was a modification of pMC1neopA (Thomas and Capecchi et al., 1987; G00-354-270). Initially, a neo-tk cassette was constructed by cloning a Bg....
8.	HNF-3beta (-/-)	The HNF-3beta (hepatocyte nuclear factor-3beta) genomic clone used in this study was obtained from a 129/Sv mouse strain lambda-dash genomic library (gift of Andrew Reau....