Epidermal growth factor receptor (Egfr)

Phenotype depends on genetic background:

CF-1 background:

Degeneration of the inner cell mass

Peri-implantation death

129/Sv background:

Placental defects

Death at mid-gestation

CD-1 background:

Abnormalities in skin, kidney, brain, liver, and gastrointestinal tract (Threadgill et al., 1995)

Death by 3 weeks

129/Sv X C57BL/6 background:

Death at birth

129/Sv X C57BL/6 X MF1 background:

Death by postnatal day 20

Phenotypic abnormalities in newborn mice (Sibilia and Wagner, 1995)

Open eyes

Rudimentary whiskers

Immature lungs

Defects in the epidermis

((egfr))

	Line Name	DNA Construct
1.	EGF-R (+/-)	A mouse genomic EGF-R (epidermal growth factor receptor) DNA segment was isolated from a lambda-based genomic DNA library using human EGF-R cDNA as probe. After identif....
2.	EGF receptor-CAT li	Transgenic mice were generated using a construct in which the bacterial acetyltransferase (CAT) gene was ligated in between 2.2 kbp of the 5' flanking region and the enh....
3.	EGF receptor-CAT li	Transgenic mice were generated using a construct in which the bacterial acetyltransferase (CAT) gene was ligated in between 2.2 kbp of the 5' flanking region and the enh....
4.	EGF receptor-CAT li	Transgenic mice were generated using a construct in which the bacterial acetyltransferase (CAT) gene was ligated in between 2.2 kbp of the 5' flanking region and the enh....
5.	EGF receptor-CAT li	Transgenic mice were generated using a construct in which the bacterial acetyltransferase (CAT) gene was ligated in between 2.2 kbp of the 5' flanking region and the enh....
6.	EGF receptor-CAT li	Transgenic mice were generated using a construct in which the bacterial acetyltransferase (CAT) gene was ligated in between 2.2 kbp of the 5' flanking region and the enh....
7.	EGF receptor-CAT li	Transgenic mice were generated using a construct in which the bacterial acetyltransferase (CAT) gene was ligated in between 2.2 kbp of the 5' flanking region and the enh....
8.	EGF receptor-CAT li	Transgenic mice were generated using a construct in which the bacterial acetyltransferase (CAT) gene was ligated in between 2.2 kbp of the 5' flanking region and the enh....
9.	EGF receptor-CAT li	Transgenic mice were generated using a construct in which the bacterial acetyltransferase (CAT) gene was ligated in between 2.2 kbp of the 5' flanking region and the enh....
10.	EGF-R (-/-)	A mouse genomic EGF-R (epidermal growth factor receptor) DNA segment was isolated from a lambda-based genomic DNA library using human EGF-R cDNA as probe. After identif....