D1A dopamine receptors
Normal coordination
Normal locomotion
Normal level of enkephalin mRNA in striatal neurons expressing D2 receptors
Normal development of striatal neurons expressing functional D1A receptors
Growth retardation
Significant decrease in rearing behavior
Changes in striatum
Absent D1A receptor binding in striatum
Reduced level of substance P mRNA in striatal neurons expressing D1A receptors
Death shortly after weaning age unless given hydrated food
| Line Name | DNA Construct | |
|---|---|---|
| 1. | D1 (+/-) | Six oligonucleotide primers were used in PCRs with DNA isolated from mouse D3 ES cells as template. The sequences of these primers are 5'-TCCAAGGTGACCAACTTCTTGT, 5'-TGG.... |
| 2. | D1 (-/-) | Six oligonucleotide primers were used in PCRs with DNA isolated from mouse D3 ES cells as template. The sequences of these primers are 5'-TCCAAGGTGACCAACTTCTTGT, 5'-TGG.... |
| 3. | D1 (-/-) | Six oligonucleotide primers were used in PCRs with DNA isolated from mouse D3 ES cells as template. The sequences of these primers are 5'-TCCAAGGTGACCAACTTCTTGT, 5'-TGG.... |
