DNA repair gene (ERCC-1)
Runted at birth
Liver failure
Polyploidy in perinatal liver Severe aneuploidy by 3 weeks of age Elevated p53 levels in liver, brain, and kidney Death before weaningMcWhir et al., 1993
| Line Name | DNA Construct | |
|---|---|---|
| 1. | ERCC-1 (+/-) | PCR was used to isolate the exon 4-6 region of the excision repair cross complementing gene (ERCC-1) from ES cell DNA as a 2.3 kb fragment that was cloned into pBluescri.... |
| 2. | ERCC-1 (-/-) | PCR was used to isolate the exon 4-6 region of the excision repair cross complementing gene (ERCC-1) from ES cell DNA as a 2.3 kb fragment that was cloned into pBluescri.... |
