ID   MTDM_MOUSE     STANDARD;      PRT;  1502 AA.
AC   P13864;
DT   01-JAN-1990 (REL. 13, CREATED)
DT   01-OCT-1993 (REL. 27, LAST SEQUENCE UPDATE)
DT   01-FEB-1994 (REL. 28, LAST ANNOTATION UPDATE)
DE   DNA (CYTOSINE-5)-METHYLTRANSFERASE (EC 2.1.1.37) (DNA
DE   METHYLTRANSFERASE) (DNA METASE).
OS   MUS MUSCULUS (MOUSE).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; RODENTIA.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 89094873. [MEDLINE, MEDLARS]
RA   BESTOR T.H., LAUDANO A., MATTALIANO R., INGRAM V.;
RL   J. MOL. BIOL. 203:971-983(1988).
RN   [2]
RP   REVISIONS.
RA   BESTOR T.H.;
RL   SUBMITTED (FEB-1992) TO EMBL/GENBANK/DDBJ DATA BANKS.
CC   -!- FUNCTION: METHYLATES CG RESIDUES.
CC   -!- CATALYTIC ACTIVITY: S-ADENOSYL-L-METHIONINE + DNA = S-ADENOSYL-L-
CC       HOMOCYSTEINE + DNA CONTAINING 5-METHYLCYTOSINE.
CC   -!- SIMILARITY: HIGH, TO OTHER EUKARYOTIC DNA METASE.
CC   -!- SIMILARITY: SOME TO BACTERIAL RESTRICTION SYSTEMS
CC       METHYLTRANSFERASES.
DR   EMBL; X14805; G50724; -. [EMBL / GenBank]
DR   PIR; S01845; S01845.
DR   PROSITE; PS00094; C5_MTASE_1.
DR   PROSITE; PS00095; C5_MTASE_2.
DR   PRODOM [Domain structure / List of seq. sharing at least 1 domain]
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   TRANSFERASE; METHYLTRANSFERASE; DNA-BINDING.
FT   DOMAIN      533    575       CYS/ARG/LYS-RICH.
FT   ACT_SITE   1111   1111       BY SIMILARITY.
SQ   SEQUENCE   1502 AA;  169703 MW;  A156B824 CRC32;
     MADSNRSPRS RPKPRGPRRS KSDSDTLFET SPSSVATRRT TRQTTITAHF TKGPTKRKPK
     EESEEGNSAE SAAEERDQDK KRRVVDTESG AAAAVEKLEE VTAGTQLGPE EPCEQEDDNR
     SLRRHTRELS LRRKSKEDPD REARPETHLD EDEDGKKDKR SSRPRSQPRD PAAKRRPKEV
     RARAGSSRDS EDRDEDEREE KRRKTTRKKL ESHTVPVQSR SERKAAQSKS VIPKINSPKC
     PECGQHLDDP NLKYQQHPED AVDEPQMLTS EKLSIYDSTS TWFDTYEDSP MHRFTSFSVY
     CSRGHLCPVD TGLIEKNVEL YFSGCAKAIH DENPSMEGGI NGKNLGPINQ WWLSGFDGGE
     KVLIGFSTAF AEYILMEPSK EYEPIFGLMQ EKIYISKIVV EFLQNNPDAV YEDLINKIET
     TVPPSTINVN RFTEDSLLRH AQFVVSQVES YDEAKDDDET PIFLSPCMRA LIHLAGVSLG
     QRRATRRVMG ATKEKDKAPT KATTTKLVYQ IFDTFFSEQI EKYDKEDKEN AMKRRRCGVC
     EVCQQPECGK CKACKDMVKF GGTGRSKQAC LKRRCPNLAV KEADDDEEAD DDVSEMPSPK
     KLHQGKKKKQ NKDRISWLGQ PMKIEENRTY YQKVSIDEEM LEVGDCVSVI PDDSSKPLYL
     ARVTALWEDK NGQMMFHAHW FCAGTDTVLG ATSDPLELFL VGECENMQLS YIHSKVKVIY
     KAPSENWAME GGTDPETTLP GAEDGKTYFF QLWYNQEYAR FESPPKTQPT EDNKHKFCLS
     CIRLAELRQK EMPKVLEQIE EVDGRVYCSS ITKNGVCYRL GDSVYLPREA FTFNIKVASP
     VKRPKKDPVK ENPVPRDTYR KYSDYIKGRN LDAPEPYRIG RIKEIHCGKK KGKVNEADIK
     LRLYKFYRPE NTHRSYNGSY HTDINMLCWS DEEAVVNFSD VQGRCTVEYR EDLLESIQDY
     SQGGPDRFYF LEAYNSKTKN FEDPPNHARS PGNKGKGKGK GKGKGKHQVS EPKEPEAAIK
     LPKLRTLDVF SGCGGLSEGF HQAGISETLW AIEMWDPAAQ AFRLNNPGTT VFTEDCNVLL
     KLVMAGEVTN SLGQRLPQKG DVEMLCGGPP CQGFSGMNRF NSRTYSKFKN SLVVSFLSYC
     DYYRPRFFLL ENVRNFVSYR RSMVLKLTLR CLVRMGYQCT FGVLQAGQYG VAQTRRRAII
     LAAAPGEKLP LFPEPLHVFA PRACQLSVVV DDKKFVSNIT RLSSGPFRTI TERDTMSDLP
     EIQNGASNSE IPYNWRATVQ VPEAAARITL PAHPQGPYLQ GHEPTGGCPH AHIPLFPGSD
     WRDLPNIQVR LGDGVIADKL QYTFHDVKNG YSSTGALRGV CSCAEGKACD PESRQFSTLI
     PWCLPHTGNR HNHWAGLYGR LEWDGFFSTT VTNPEPMGKQ GRVLHPEQHR VVSVRECARS
     QGFPDSYRFF GNILDRHRQV GNAVPPPLAK AIGLEIKLCL LSSARESASA AVKAKEEAAT
     KD
//