Ctla-4

Ctla-4

Spontaneous T-cell proliferation in mice <br>
<img align=bottom src= Accumulation of T cell blasts with up-regulated activation markers in lymph nodes and spleens
Infiltration by blast cells of liver, heart, lung, and pancreas
Elevation of serum immunoglobulin
Death by 3 to 4 weeks of age

Waterhouse, 1995: Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
Science 270, 985-988 (1995) [96069818]
(View Citation format,Abstract format,MEDLARS format,ASN.1 format,Save As..., or 30 Related MEDLINE citations)

Normal thymocyte profiles

Normal thymocyte development

Normal T cell antigen receptor signaling

Lack of increase in thymocyte production

Lymphoproliferative disorder

Reference:

Chambers CA, Cado D., Truong T., Allison JP.: Thymocyte development is normal in CTLA-4-deficient mice. Proc Natl Acad Sci USA Aug 19; 94 (17):9296-9301.

METHODOLOGY ( FROM T-BASE)

( (ctla-4))

( (ctla-4))

Line Name DNA Construct

1. B7 (-/-) A targeting vector that allowed positive and negative selection was generated by insertion of the neo gene driven by the mouse phosphoglycerol kinase (PGK) promoter into....
2. NFAT1 (-/-) NFAT1 gene fragments were cloned from a genomic library derived from mouse strain 129/Sv (Stratagene). A 4.5-kb region of the NFAT1 gene was deleted by XhoI....

Database links