Ciliary neuotrophic factor

No early onset of Huntington’s disease

Reference:

Rubinsztein DC, Leggo J., Chiano M., Korn S., Dodge A., Norbury G., Rosser E., Craufurd D.: Homozygotes and heterozygotes for ciliary neurotrophic factor null alleles do not show earlier onset of Huntington’s disease. Neurology 1997 Sep;49 (3):890-892.

CNTF (+/-) motor ne	The CNTF (Ciliary NeuroTrophic Factor) targeting vector was constructed by subcloning a 9.5-kb Kpni-BglII fragment containing exon 1 of murine genomic CNTF DNA into....
CNTF (-/-) motor ne	The CNTF (Ciliary NeuroTrophic Factor) targeting vector was constructed by subcloning a 9.5-kb Kpni-BglII fragment containing exon 1 of murine genomic CNTF DNA into....