C/EBP Alpha


	C/EBP Alpha Failure to store hepatic glycogen Presence of only 50 to 70% of the normal amounts of glycogen synthase messenger RNA Delay in the induction of the transcription of genes for phosphoenolpyruvate carboxykinase and glucose 6 phosphatase Failure of hepatocytes and adipocytes to accumulate lipid Reduced expression of the gene of the uncoupling protein, the defining marker of the brown adipose tissue Death due to hypoglycemia within 8 hours of birth Wang et al, 1995 Normal expression of transferrin, apolipoprotein B, and insulin-like growth factor I gene Reduced level of bilirubin UDP-glucuronosyltransferase expression in the liver Severe jaundice due to an increase in unconjugated serum bilirubin Reduced phosphoenolpyruvate carboxykinase, glycogen synthase, and factor IX Reference: Lee YH, Sauer B, Johnson PF, Gonzalez FJ. Disruption of the c/ebp alpha gene in adult mouse liver. Mol Cell Biol 1997 Oct;17 (10):6014-6022. METHODOLOGY ( FROM T-BASE) Database links

C/EBP Alpha

Failure to store hepatic glycogen: Presence of only 50 to 70% of the normal amounts of glycogen synthase messenger RNA; Delay in the induction of the transcription of genes for phosphoenolpyruvate carboxykinase and glucose 6 phosphatase
Failure of hepatocytes and adipocytes to accumulate lipid: Reduced expression of the gene of the uncoupling protein, the defining marker of the brown adipose tissue
Death due to hypoglycemia within 8 hours of birth

Wang et al, 1995

Normal expression of transferrin, apolipoprotein B, and insulin-like growth factor I gene
Reduced level of bilirubin UDP-glucuronosyltransferase expression in the liver
Severe jaundice due to an increase in unconjugated serum bilirubin
Reduced phosphoenolpyruvate carboxykinase, glycogen synthase, and factor IX

Reference:

Lee YH, Sauer B, Johnson PF, Gonzalez FJ. Disruption of the c/ebp alpha gene in adult mouse liver. Mol Cell Biol 1997 Oct;17 (10):6014-6022.

METHODOLOGY ( FROM T-BASE)

Database links