FRONTIERS IN BIOSCIENCE; GENE KNOCKOUT DATABASE
	CD22 Augmented immune response Heightened calcium fluxes and cell proliferation obtained at lower ligand concentrations Hyperresponsive to receptor signaling in splenic B cells Expansion of peritoneal B-1 cell population Increased serum titers of autoantibody O'Keefe, G. T. Williams, S. L. Davies, M. S. Neuberger: Hyperresponsive B Cells in CD22-Deficient Mice. Science 274, 798 (1996) Database Links