CD18
Viable
Increased circulating neutrophil counts
Defects in response to induced peritonitis
Delays in transplantation rejection
PL/J backcrossed mutant homozygotes develop chronic inflammatory skin disease at 11 weeks
| Line Name | DNA Construct | |
|---|---|---|
| 1. | CD18 (-/-) partiall | To prepare the construct for homologous recombination in the CD18 gene, a murine (Swiss strain) genomic DNA library (no. 946301, Stratagene) was screened using the mouse.... |
| 2. | CD18 (+/-) | To prepare the construct for homologous recombination in the CD18 gene, a murine (Swiss strain) genomic DNA library (no. 946301, Stratagene) was screened using the mouse.... |
| 3. | CD18 (-/-) | To prepare the construct for homologous recombination in the CD18 gene, a murine (Swiss strain) genomic DNA library (no. 946301, Stratagene) was screened using the mouse.... |
