c-ret
Renal agenesis or severe dysgenesis
Lack of enteric neurons throughout the digestive tract
Death soon after birth
Schuchardt et al., 1994
| Line Name | DNA Construct | |
|---|---|---|
| 1. | ret-k (+/-) | A targeting construct was designed to insert a neo(R) gene into the c-ret gene, simultaneously deleting 0.8 kilobases (kb) of DNA, including the codon for an invariant l.... |
| 2. | ret-k (-/-) | A targeting construct was designed to insert a neo(R) gene into the c-ret gene, simultaneously deleting 0.8 kilobases (kb) of DNA, including the codon for an invariant l.... |
