c-rel proto-oncogene

 Normal development in mice
 Impaired humoral immunity
 Mature B and T cells unresponsive to most mitogenic stimuli
 Defective interleukin-2 expression

Kontgen, 1995
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.
Genes Dev 9, 1965-1977 (1995) [95377645]
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