ß₂-microglobulin (ß₂m)

Apparently normal
Fertile
Normal distribution of gamma delta, CD4+8+ and CD4+8- T cells
Normal development of functional TCR(+)-alpha beta CD8+ CTLs in response to tumor cell injection
Little if any functional MHC I
No detectable class I antigens
Gross deficiency in CD4-CD8+ T cells
Defective CD4-8+ T cell-mediated cytotoxicity
Massive intraperitoneal accumulation of highly lytic CD8+ CTLs after intraperitoneal injection of tumor cells
Delayed tumor cell rejection
Ability to resolve low dose of Listeria monocytogenes

Exacerbated clinical course of L. monocytogenes infection

Delayed clearance

Koller et al., 1990
Zijlstra et al., 1990
Bix et al., 1991
Apasov and Sitkovsky et al., 1994
Ladel et al., 1994

( (beta2m))

	Line Name	DNA Construct
1.	beta2-m (-/-) and N	Plasmid pKCbeta2B contains the entire beta2m (beta2-microglobulin) gene within an 8.4-kbp XhoI fragment. The 5' XhoI-BamHI fragment of....
2.	beta2-m (+/-) and N	Plasmid pKCbeta2B contains the entire beta2m (beta2-microglobulin) gene within an 8.4-kbp XhoI fragment. The 5' XhoI-BamHI fragment of....
3.	beta2m (+/-) and T.	Plasmid pKCbeta2B contains the entire beta2m (beta2-microglobulin) gene within an 8.4-kbp XhoI fragment. The 5' XhoI-BamHI fragment of....
4.	beta2-microglobulin	Plasmid pKCbeta2B contains the entire beta2m (beta2-microglobulin) gene within an 8.4-kbp XhoI fragment. The 5' XhoI-BamHI fragment of....
5.	beta2-microglobulin	Plasmid pKCbeta2B contains the entire beta2m (beta2-microglobulin) gene within an 8.4-kbp XhoI fragment. The 5' XhoI-BamHI fragment of....
6.	beta2-microglobulin	Plasmid pKCbeta2B contains the entire beta2m (beta2-microglobulin) gene within an 8.4-kbp XhoI fragment. The 5' XhoI-BamHI fragment of....
7.	beta2m (-/-)	Plasmid pKCbeta2B contains the entire beta2m (beta2-microglobulin) gene within an 8.4-kbp XhoI fragment. The 5' XhoI-BamHI fragment of....
8.	beta2-m (-/-) and t	Plasmid pKCbeta2B contains the entire beta2m (beta2-microglobulin) gene within an 8.4-kbp XhoI fragment. The 5' XhoI-BamHI fragment of....
9.	beta2-m (+/-) and t	Plasmid pKCbeta2B contains the entire beta2m (beta2-microglobulin) gene within an 8.4-kbp XhoI fragment. The 5' XhoI-BamHI fragment of....
10.	beta2m (-/-) and T.	Plasmid pKCbeta2B contains the entire beta2m (beta2-microglobulin) gene within an 8.4-kbp XhoI fragment. The 5' XhoI-BamHI fragment of....
11.	beta2-m (+/-) and V	Plasmid pKCbeta2B contains the entire beta2m (beta2-microglobulin) gene within an 8.4-kbp XhoI fragment. The 5' XhoI-BamHI fragment of....
12.	beta2-m (-/-) and V	Plasmid pKCbeta2B contains the entire beta2m (beta2-microglobulin) gene within an 8.4-kbp XhoI fragment. The 5' XhoI-BamHI fragment of....
13.	beta2-m (-/-) & tu	Plasmid pKCbeta2B contains the entire beta2m (beta2-microglobulin) gene within an 8.4-kbp XhoI fragment. The 5' XhoI-BamHI fragment of....
14.	beta2-m (-/-) & L.