Atm
Degeneration of neurons
Degeneration of synapses
Degeneration of neuropil
Glial activation
Reference:
Kuljis RO, Xu Y, Aguila MC, Baltimore D.: Degeneration of neurons, synapses, and neuropil and glial activation in a murine atm knockout model of ataxia-a-telangiectasia. Proc Natl Acad Sci USA 1997 Nov 11;94 (23):12688-12693.
| Line Name | DNA Construct | |
|---|---|---|
| 1. | ATM (+/-) | The sequence of the exons disrupted corresponded to the human ATM (ataxia-telangiectasia) cDNA from nucleotides 8619 to 8831. In addition, Xu et al., 1996 could not.... |
| 2. | Atm (+/-) | A 236 bp PCR fragment corresponding to nucleotides 5381-5617 of human ATM (ataxia telangiectasia) (Savitsky et al., 1995b; REF:763008), where 3 of 11 initial mutation.... |
| 3. | ATM (-/-) | The sequence of the exons disrupted corresponded to the human ATM (ataxia-telangiectasia) cDNA from nucleotides 8619 to 8831. In addition, Xu et al., 1996 could not.... |
| 4. | Atm (-/-) | A 236 bp PCR fragment corresponding to nucleotides 5381-5617 of human ATM (ataxia telangiectasia) (Savitsky et al., 1995b; REF:763008), where 3 of 11 initial mutation.... |
