FRONTIERS IN BIOSCIENCE;



Squamous cell carcinoma of the oral cavity

Location: lower lip, tongue, floor of the mouth

Etiology and pathogenesis

Tobacco
Cigars
Alcohol
Leukoplakia
White patch on the oral mucosa
Erythroplakia
Red velvety lesion
Herpes simplex virus (HSV)
Human papilloma virus (HPV)
Plummer-Vinson syndrome
Iron deficiency anemia
Dysphagia

Clinical findings

Painless mass
Ulcerated lesion
Exophytic lesion
Infiltrative lesion
Friable
Referred otalgia
Bleeding
Palpable cervical mass
Foul odor
Trismus
Hypoglossal nerve involvement
Ipsilateral tongue weakness
Palpable submandibular, submental lymph nodes
Change in voice (base of the tongue)