Solitary neurofibroma

Location: evenly distributed over the body surface

Superficial lesions
Slow growing
Painless nodules
Major nerve involvement
Fusiform fashion

Peripheral neurofibromatosis

Caf 'eau lait spots
Pigmented macular lesions (Unexposed surfaces of the body)
Axillary freckle sign (Axilla)
Lisch nodules (Pigmented hamartomas of the iris)
Slow growing tumors
Increased during puberty & pregnancy
Sudden increase in size (Malignant change)
Skeletal abnormalities
Erosive defects
Angular scoliosis
Congenital bowing of the long bones
Scalloping of the vertebra
Gynecomastia

Central neurofibromatosis Neurilemmoma

Acoustic neuroma

Eighth cranial nerve involvement
Deafness
Usually bilateral
Headache

Plexiform neurofibroma

Involves major nerve
Distorts & converts it into convoluted mass
Elephantiasis neuromatosa
Entire extremity is enlarged
Overlying skin is loose
Redundant
Hyperpigmented