[Frontiers in Bioscience S3, 777-787, January 1, 2011]
Skin cancer chemoprevention by alpha-santalol
Xiaoying Zhang1, Chandradhar Dwivedi2
1Department of Biology, Shanghai chempartner Co., LTD, Shanghai, China 201203, 2 Department of Pharmaceutical Sciences, South Dakota State University, Brookings, SD 57007
TABLE OF CONTENT
Alpha-santalol, a naturally occurring terpenoid, has been shown to have chemopreventive effects on both 7, 12-dimethylbenz(a)anthracene (DMBA)-initiated and 12-O- tetradecanoylphorbol-13-acetate (TPA)-promoted skin cancer development in CD-1 and SENCAR mice, and UVB-induced skin cancer developments in SKH-1 hairless mice in a concentration-dependent manner. Studies have demonstrated that a-santalol could be effective against skin carcinogenesis through both induction of apoptosis via caspase activation together with dissipation of mitochondria membrane potential and cytochrome c release in A431 cells, and inhibition of cell growth via induction of G2/M phase arrest in both A431 cells and melanoma UACC-62 cells by altering multiple cell cycle regulatory proteins and complexes. This review summarizes the chemopreventive effects and molecular mechanisms of a-santalol on skin cancer development in both animal models and skin cancer cell lines.