[Frontiers in Bioscience S2, 1169-1188, June 1, 2010]
Important roles of Akt/PKB signaling in the aging process
Miaozong Wu 1,2,3, Bin Wang 4, Jia Fei 5, Nalini Santanam 5, Eric R. Blough1,2,3,5
1Cell Differentiation and Development Center, 2Department of Biological Sciences, 3Department of Exercise Science, Sport and Recreation, 4Department of Chemistry, 5Department of Pharmacology, Physiology and Toxicology, Marshall University, Huntington WV, 25755
TABLE OF CONTENTS
The increased costs associated with an ever-growing aged population are expected to pose a significant burden on health care resources. From a biological standpoint, aging is an accelerated deteriorative process in tissue structure and function that is associated with higher morbidity and mortality. The Akt / protein kinase B (PKB) is a family of serine / threonine protein kinases, which play prominent roles in a diverse number of processes including cell survival, cell growth, gene expression, apoptosis, protein synthesis, energy metabolism and oncogenesis. It is likely that age-related changes in tissue structure and function are related to alterations in Akt expression and Akt-dependent signaling. Here we review the role that Akt may play in the aging process and attempt, where possible, to highlight how these data may lead to new directions of inquiry and clinical relevance to the aged.