[Frontiers in Bioscience 15, 1023-1039, June 1, 2010]

TRPC channels in smooth muscle cells

Jose C. Gonzalez-Cobos, Mohamed Trebak

The Center for Cardiovascular Sciences, Albany Medical College, Albany, NY


1. Abstract
2. Calcium signaling in smooth muscle cells
3. Contribution of TRPC channels to smooth muscle calcium signals
4. TRPC channels and vascular smooth muscle phenotypic modulation
5. Activation mechanisms of TRPC channels in smooth muscle
6. TRPC channels in vascular physiology
7. Implications of TRPC channels in vascular disease
8. Conclusion
9. Acknowledgments
10. References


Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the gastrointestinal tract. TRPC channels have recently emerged as important players in the control of smooth muscle function. This review will focus on the retrospective analysis of studies proposing contributions of TRPC channels to native calcium entry pathways in smooth muscle and to physiological and pathophysiological responses with emphasis on the vascular system.