(Frontiers in Bioscience 15, 883-900, June 1, 2010)
Replication protein A: directing traffic at the intersection of replication and repair
Greg G. Oakley1, Steve M. Patrick2
1College of Dentistry, University of Nebraska Medical Center, Lincoln, Nebraska 68583, 2Department of Biochemistry and Cancer Biology, University of Toledo Medical Center, Toledo, Ohio 43614
TABLE OF CONTENTS
Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much progress has been made on elucidating critical roles for RPA in other DNA metabolic pathways. RPA has been shown to be required for DNA replication, DNA repair, DNA recombination, and the DNA damage response pathway with roles in checkpoint activation. This review summarizes the current understanding of RPA structure, phosphorylation and protein-protein interactions in mediating these DNA metabolic processes.