[Frontiers in Bioscience E1, 528-536, June 1, 2009]

Proliferation of cardiomyocytes: a question unresolved

Maria De Falco1, Gilda Cobellis2, Antonio De Luca3

1 Department of Biological Sciences, Section of Evolutionary and Comparative Biology, University Federico II of Naples, Naples, Italy, 2 Department of General Pathology and Oncology, Second University of Naples, Naples, Italy, 3 Department of Medicine and Public Health, Section of Anatomy, Second University of Naples, Naples, Italy


1. Abstract
2. Introduction
3. Perspectives
4. Acknowledgements
5. References


In the past, human heart has been considered a post-mitotic organ formed by cells, like adult cardiomyocytes, terminally differentiated and incapable of proliferation. This paradigm has been shaken by recent works indicating that postnatal adult cardiomyocytes are able to re-enter in the cell cycle and proliferate. In this view, the understanding of main candidates regulating cardiomyocyte cell cycle is of vital importance for future clinical approach.