[Frontiers in Bioscience E1, 332-340, June 1, 2009]

Targeting vectors for cancer gene therapy

Kiminori Nakamura1, Kazunori Kato1, Toshihiro Tanaka1, 2, Hirofumi Hamada1

1Department of Molecular Medicine, Sapporo Medical University, Japan, 2Department of Biochemistry, School of Medicine, Fukuoka University, Japan, Nishi 17-Chome,Minami 1-Jo,Chuo-ku,Sapporo,060-8556, Japan


1. Abstract
2. Introduction
3. Tumor-specific gene transfer system
4. Gene transfer by adenovirus FZ33 via antibody
5. Candidates for target molecules
6. ErbB2-targeted selective cancer gene therapy via FZ33 fiber-modified adenoviral
7. Systematic search for novel target molecules
8. Conclusions
9. References


Establishment of a system that allows selective gene transfer to a tumor is expected to enable targeted therapy. Using a combination of fiber-modified adenovirus and antibody to a cell surface antigen, we have explored methods to enhance the selectivity of gene transfer. In addition, we aimed to establish a systematic screening method to search for antibody and cell surface target candidates for providing highly selective gene transfer to a variety of malignant tumors.