[Frontiers in Bioscience 14, 2599-2630, January 1, 2009]
Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis
Jaap Mulder1, Saul J. Karpen3, Uwe J.F. Tietge1, Folkert Kuipers1,2
1Department of Pediatrics Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands, 2Department of Laboratory Medicine, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands, 3Texas Children's Liver Center, Department of Pediatrics/GI, Hepatology & Nutrition, Baylor College of Medicine, Houston, TX
TABLE OF CONTENTS
Inflammation-induced cholestasis (IIC) is a frequently occurring phenomenon. A central role in its pathogenesis is played by nuclear receptors (NRs). These ligand-activated transcription factors not only regulate basal expression of hepatobiliary transport systems, but also mediate adaptive responses to inflammation and possess anti-inflammatory characteristics. The latter two functions may be exploited in the search for new treatments for IIC as well as for cholestasis in general. Current knowledge of the pathogenesis of IIC and the dual role NRs in this process are reviewed. Special interest is given to the use of NRs as potential targets for intervention.