[Frontiers in Bioscience 14, 2089-2102, January 1, 2009]

Ovarian cancer: pathology, biology, and disease models

Daniel G. Rosen, Gong Yang, Guangzhi Liu, Imelda Mercado-Uribe, Bin Chang, Xue (Sherry) Xiao, Jingfang Zheng, Feng-Xia Xue, Jinsong Liu

Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77005-4095


1. Abstract
2. Introduction
3. Ovarian serous carcinoma
4. Ovarian endometrioid carcinoma
5. Ovarian mucinous carcinoma
6. Ovarian clear cell carcinoma
7. HOX genes in ovarian cancer histogenesis
8. Epithelial-stromal interactions in cancer
9. Senescent fibroblasts in ovarian cancer promotion 10. Inflammation and ovarian carcinogenesis 11. Models of ovarian cancer 12. Acknowledgements 13. References


Epithelial ovarian cancer, which comprises several histologic types and grades, is the most lethal cancer among women in the United States. In this review, we summarize recent progress in understanding the pathology and biology of this disease and in development of models for preclinical research. Our new understanding of this disease suggests new targets for therapeutic intervention and novel markers for early detection of disease.