[Frontiers in Bioscience 14, 2089-2102, January 1, 2009]
Ovarian cancer: pathology, biology, and disease models
Daniel G. Rosen, Gong Yang, Guangzhi Liu, Imelda Mercado-Uribe, Bin Chang, Xue (Sherry) Xiao, Jingfang Zheng, Feng-Xia Xue, Jinsong Liu
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77005-4095
TABLE OF CONTENTS
Epithelial ovarian cancer, which comprises several histologic types and grades, is the most lethal cancer among women in the United States. In this review, we summarize recent progress in understanding the pathology and biology of this disease and in development of models for preclinical research. Our new understanding of this disease suggests new targets for therapeutic intervention and novel markers for early detection of disease.