[Frontiers in Bioscience 14, 1596-1605, January 1, 2009]

Mechanisms of neutrophil transendothelial migration

Eun Young Choi1, Sentot Santoso2, Triantafyllos Chavakis1

1 Experimental Immunology Branch, NCI, NIH, Bethesda, MD 20892, 2 Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig University Giessen, D-35392 Giessen, Germany


1. Abstract
2. Introduction
3. The multistep process of neutrophil recruitment
4. Neutrophil transendothelial migration
4.1. VE-cadherin
4.2. JAMs and related molecules
4.3. Platelet endothelial cell adhesion molecule-1 (PECAM-1) and CD99
4.4. ICAM-1
5. Conclusions
6. References


Neutrophil recruitment is an integral part of the immune response to infection as well as of inflammatory disorders. The process of neutrophil extravasation comprises a complex multistep cascade that is orchestrated by a tightly coordinated sequence of adhesive interactions with vessel wall endothelial cells. Adhesion receptors as well as signaling molecules in both neutrophils and endothelial cells regulate the recruitment of neutrophils into the site of inflammation or infection. The present review will focus on novel aspects with regards to the last step of neutrophil recruitment, namely the transmigration of neutrophils through endothelial cells.